Role of NAD+ metabolism in muscle stem cells for skeletal muscle regeneration at Novo Nordisk Foundation Center for Basic Metabolic Research

Posted 1 week ago

Position: This is a project proposal for a student opportunity at the Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR).

Background: The ability to repair damaged tissue and continuously respond to stressful stimuli is essential to preserve whole-body function throughout life. Muscle stem cells (satellite cells) are an integral part of this process and their loss of function with age contributes to degenerative diseases. NAD+ has emerged as an important and vital cofactor linking energy status with adaptive cellular and organismal responses. Decreasing NAD+ levels could therefore prompt the development of many of the ailments associated with aging. While the levels of NAD+ in skeletal muscle decrease with age, NAD+ levels can be restored by the administration of NAD+ precursors such as nicotinamide riboside (NR) or nicotinamide mononucleotide (NMN). This also restores lost muscle mass and ameliorates functional defects of aged murine muscles.

The project: We aim to determine how perturbations in NAD+ metabolism in satellite cells affect their ability to proliferate and differentiate, and to regenerate skeletal muscle after damage. We will perform experiments in mice in which NAD+ levels in satellite cells have been manipulated either by genetically targeting of the pathways that generate NAD+ or by providing NAD+ precursors.

The student: You are highly motivated and enthusiastic to learn about muscle stem cells and to perform the experimental and analytical techniques associated with this project.

Contact: Please contact Associate Professor Jonas Treebak (jttreebak@sund.ku.dk) for more information related to this project.

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